Japan

The researchers from Osaka University showed how bone erosion caused by cholesteatoma occurs. This study showed that a subset of cells called osteoclastogenic fibroblasts expresses a protein, activin A, which causes the breakdown of the bones. Because of this discovery, novel medical treatments can be developed as first-line management for cholesteatomas.

Soft metal-organic polymer networks can adsorb selected molecules from gas mixtures by opening pores when the molecules bind.

Osaka Metropolitan University researchers have shown that within the helium-8 nucleus (with two protons and six neutrons), there are two clusters of two neutrons each, existing around the helium-4 core. Furthermore, they demonstrated the shape these clusters take. Nuclei with an imbalance of protons and neutrons, such as in helium-8, do not naturally exist on Earth but are believed to be abundantly generated in cosmic environments like the interiors of stars through the process of nucleosynthesis. This study’s findings provide new insights into the still largely unknown binding forms of neutrons and deepen our understanding of the origins of the elements that surround us.

Molecules that act as connected wheels can hold long molecular chains together to modify the properties of soft polymers.

Researchers from Osaka University found that patients with persistently high levels of urinary albumin excretion in the long term are at high risk of new-onset heart failure. Preventive treatment associated with the lowering of urinary albumin excretion levels in these patients could reduce the risk of later heart failure or mortality.

Researchers from Osaka University have demonstrated a proof-of-concept for identifying single nucleotides by using quantum computing. Molecular rotation patterns—and the corresponding variations in conductance—within the nanoscale gap between two electrodes enabled the development of a quantum gate for the nucleotide adenosine monophosphate. Developing quantum gates for the other three nucleotides, and incorporating this technology into DNA sequencing workflows, could revolutionize genome analysis.

succeeded in preparing atactic C1 polymers with a high melting point of up to 130 ℃ by utilizing a hydrogen-bonding interaction among amide-linkages incorporated into the polymer side-chains.

Elucidation of global anti-aromaticity (aromaticity) in homoHPHAC+ (homoHPHAC3+) with electron-accepting to electron-donating substituents

What does healthy aging look like? For answers, Hiroshima University environmental health expert Dr. Saori Kashima taps into a new science dedicated to Earth’s longevity.

Researchers from Osaka University use quasi-elastic neutron scattering to get a close look at the behavior of water molecules in a semiclathrate hydrate crystal. They found that the molecules showed fast reorientation with an activation energy similar to that of cleaving a hydrogen bound. This rapid relaxation time in the solid electrolyte is expected to lead to efficient, cost-effective, and safe applications for semiclathrate hydrates in batteries and thermal storage materials.

An exquisitely preserved fossil forest from Japan provides missing links and helps reconstruct a whole Eurasia plant from the late Miocene epoch.

Researchers from the Institute of Industrial Science, The University of Tokyo, provide physical insights into porous soft materials, which will facilitate the design of many energy, medical, and other technologies.

A joint research group at Osaka Metropolitan University conducted a survey on prevalence of obesity and factors associated with low obesity among 423 adolescents between the ages of 14 and 19 living in Harare, Zimbabwe. The results revealed that 15.8% were obese or overweight. The study also revealed that 27.1% of the participants had low obesity awareness, which was significantly related to parents/guardians' lack of formal education and insufficient knowledge about eating habits.

RNases have been proposed as a treatment against systemic autoimmune diseases. Researchers from Osaka University showed that RNases have a dual action. In some cases, RNases are detrimental and stimulate the immune response by promoting the binding of antibodies to their targets. These findings will improve the understanding and treatment of systemic autoimmune disorders.

Researchers from Osaka University have developed a fluorescent sensor that may be useful for understanding how cells recognize themselves versus other cells when making connections in the brain. Specifically, their sensor can be used to visualize not only connections between cells, but also the disassociation of these interactions. Because neuronal self-connectivity has been implicated in brain disorders like epilepsy and autism, a better understanding of this process may result in improved therapies.

Researchers from Northwestern University and recently joining the Institute for Industrial Science, The University of Tokyo develop a high-throughput approach to evaluate protein folding stability in thousands of proteins .

A research team has discovered an astounding array of unexplored protein folds. This research will expand our understanding of the depth of the protein universe and the possibilities for de novo design of functional proteins.

The physiological mechanisms underlying severe burns are not well understood. Researchers at Osaka University used mass spectrometry to identify key blood proteins associated with burn mortality. Ultimately, three proteins (HBA1, TTR, SERPINF2) were very highly correlated with morality rates. Further research into these proteins and their pathways may lead to better drugs to treat people with life-threatening burns.

The entire biosynthetic pathway of actinopyridazone has been unveiled, revealing that an unprecedented carrier protein-mediated ring-forming step is key to its synthesis.

Osaka Metropolitan University scientists have successfully developed a model that utilizes AI to accurately classify cardiac functions and valvular heart diseases from chest radiographs. The Area Under the Curve, or AUC, of the AI classification showed a high level of accuracy, exceeding 0.85 for almost all indicators and reaching 0.92 for detecting left ventricular ejection fraction—an important measure for monitoring cardiac function.

The composition of the Earth’s earliest atmosphere

How have the atmosphere and mantle oxidation state of the Earth changed?

Researchers at Kanazawa University report in Science Advances high-speed atomic force microscopy experiments that show the structural and chemical changes in an enzyme thought to play a vital role in modulating the strength of neural connections.

A new method for connecting neurons in neuromorphic wetware has been developed by researchers from Osaka University and Hokkaido University. The wetware comprises conductive polymer wires grown in a three-dimensional configuration, done by applying square-wave voltage to electrodes submerged in a precursor solution. The voltage can modify wire conductance, allowing the network to be trained. This fabricated network is able to perform unsupervised Hebbian learning and spike-based learning.

A new online platform to explore computationally calculated chemical reaction pathways has been released, allowing for in-depth understanding and design of chemical reactions.

A group of researchers at Osaka University used a noninvasive method to evaluate Cerebrovascular Autoregulation (CVAR) in patients after out-of-hospital cardiac arrest. The mortality rate increased significantly with the duration of time that CVAR was undetectable. It has been suggested that CVAR, a function that is normally present in the normal state, may be impaired after cardiac resuscitation. However, the relationship between CVAR function and patient prognosis has been unclear. The research examined CVAR over time, using the moving Pearson correlation coefficient calculated from regional cerebral oxygen saturation and mean blood pressure data, and performed a survival analysis using the presence or absence of CVAR as a time-dependent covariate. The findings of this study may first be useful in predicting neuroprognosis after cardiac resumption and may help avoid early withdrawal of treatment in those who may recover. In addition, they suggest that treatment and management that maintains proper CVAR after cardiac resumption may improve patient prognosis, which may be applied to the management of post-cardiac arrest resuscitation based on cerebral circulation to optimize treatment for each individual patient.

For the first time, the James Webb Space Telescope has revealed starlight from two massive galaxies hosting actively growing black holes – quasars – seen less than a billion years after the Big Bang.

A New Approach for Peripheral Annelation of Porphyrinoid

Researchers from Osaka University analyzed discussions on research governance of human genome editing in the Expert Panel on Bioethics in Japan and identified the positive roles played by related research communities, the government, and the general public in the policy-making process. It is expected to provide more effective and practical guidance for countries and organizations seeking to work with diverse stakeholders in the governance of emerging medical technologies.

Researchers from Osaka University have revealed the mechanism by which increased signaling through a pathway associated with a molecule called Wnt leads to the development of liver cancer. They identified a gene called GREB1 as a target of Wnt specifically in liver cancer. This gene alters the function of a protein called HNF4α, leading to the development of cancer. They also showed that treatment of mice with antisense oligonucleotides against GREB1 had significant anti-cancer effects.